Genetic Dissection of Behavioral Flexibility: Reversal Learning in Mice
نویسندگان
چکیده
منابع مشابه
Genetic dissection of behavioral flexibility: reversal learning in mice.
BACKGROUND Behavioral inflexibility is a feature of schizophrenia, attention-deficit/hyperactivity disorder, and behavior addictions that likely results from heritable deficits in the inhibitory control over behavior. Here, we investigate the genetic basis of individual differences in flexibility, measured using an operant reversal learning task. METHODS We quantified discrimination acquisiti...
متن کاملNeural components underlying behavioral flexibility in human reversal learning.
The ability to flexibly respond to changes in the environment is critical for adaptive behavior. Reversal learning (RL) procedures test adaptive response updating when contingencies are altered. We used functional magnetic resonance imaging to examine brain areas that support specific RL components. We compared neural responses to RL and initial learning (acquisition) to isolate reversal-relate...
متن کاملGenetic Dissection of Learning and Memory in Mice
In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome searches. Next, we briefly review more recently developed techniques, such as micr...
متن کاملBehavioral flexibility in learning to sit.
What do infants learn when they learn to sit upright? We tested behavioral flexibility in learning to sit-the ability to adapt posture to changes in the environment-in 6- to 9-month-old infants sitting on forward and backward slopes. Infants began with slant at 0°; then slant increased in 2° increments until infants lost balance. Infants kept balance on impressively steep slopes, especially in ...
متن کاملThe Dynamics of Learning and Behavioral Flexibility
Fundamental to behavior is the capacity to distinguish beneficial from detrimental environmental stimuli. In this issue of Neuron, a new study by Morrison et al. shows that underlying these processes are qualitatively different dynamical interactions between brain structures involved in processing the value of environmental stimuli.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2011
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2011.01.014